Europeans find Tamiflu resistance in seasonal flu virus

first_imgJan 29, 2008 (CIDRAP News) – An early report on the seasonal influenza strains circulating in Europe reveals that some H1N1 viruses show signs of resistance to the antiviral drug oseltamivir, the European Centre for Disease Prevention and Control (ECDC) reported this week.Of 148 influenza influenza A H1N1 samples collected in November and December in 10 European countries, 19 tested positive for resistance to oseltamivir, the ECDC said in a Jan 27 press release. Twelve of the resistant virus isolates were from Norway; the rest included one from Denmark, four from France, and two from the United Kingdom.According to ECDC’s full interim report, the oseltamivir-resistant variant, H1N1 (H274Y), is a new development this winter. (H274Y is the term for a mutation associated with resistance to the drug.) The strain is sensitive to other antivirals, which include zanamivir, amantadine, and rimantadine.The overall proportion of the oseltamivir-resistant strain among European isolates is 13%, but if the Norwegian samples are excluded from the total, the proportion for Europe falls to 5%, the report said.Though the ECDC cautioned that the findings are preliminary, it said Norway is still seeing the oseltamivir-resistant H1N1 this month and that the same mutation is being seen in other countries, including those in North America.”There are some indications that some of the same oseltamivir-resistant A H1N1 viruses are being observed at low levels in the United States,” the report said.Experts from the ECDC, the European Commission, and the World Health Organization (WHO) are assessing the significance of the findings and will release an interim joint assessment soon, based on the initial surveillance findings, the ECDC said.The WHO today held a virtual meeting of experts to discuss the findings. WHO spokesman Gregory Hartl told CIDRAP News the group agreed that more studies are needed to answer the many questions raised by the ECDC’s initial report. For example, he said experts would like to determine why antiviral resistance rates in the study vary so widely between countries and why the resistant H1N1 strain surfaced so early in the flu season.The findings need to be fleshed out, and experts are just now looking at isolates collected in January, Hartl said. “Theses are small numbers, so this is a work in progress,” he commented.Joe Bresee, MD, chief of epidemiology and prevention for the US Centers for Disease Control and Prevention’s (CDC’s) immunization services division, told CIDRAP News today that of 204 influenza samples tested by the CDC so far this season, six (2.9%) were resistant to oseltamivir. The resistant samples accounted for 5.5% of the 109 H1N1 viruses the CDC isolated, he said.”It’s interesting. Last year we wouldn’t have expected this level of resistance,” Bresee said. The CDC is continuing to monitor patterns with the oseltamivir-resistant H1N1 variant, but he said the numbers were low enough that the agency is not changing its recommendations for the treatment of seasonal influenza.The CDC has urged clinicians to stop using amantadine or rimantadine to treat influenza because circulating influenza A strains have high rates of resistance to the two drugs.Martina Rupp, a spokeswoman for Roche, the maker of Tamiflu, said the preliminary results are a contrast to previous years, when experts found little or no oseltamivir resistance, according to a Bloomberg News report. She said more surveillance is needed to establish the prevalence and geographic distribution of the resistant H1N1 variants and to gauge the impact on the drug’s efficacy.Frederick Hayden, MD, an antiviral expert with the WHO, said the change in the virus’s resistance pattern warrants concern, the Canadian Press (CP) reported yesterday. “This is not only interesting, it’s unusual and would not have necessarily been predicted by the necessary information. So it’s certainly something we’re taking seriously and trying to gather additional information [on],” he said.Though the source of the H1N1 variant is not known, ECDC experts reported that they don’t believe its emergence is related to antiviral use in Europe, because the drugs are rarely used there. They wrote that the Norwegian patients who had the resistant strain had not taken antiviral medications.The ECDC report said it’s not clear if the variant virus will be overwhelmed by more fit and oseltamivir-susceptible viruses as the influenza season progresses. “Equally, however, the resistant virus could come to spread and predominate. We simply do not know at present,” the authors reported.Evidence on the effect of the resistance mutation on viral fitness is contradictory, they noted. Some studies have shown the mutation reduces the virus’s capacity to replicate and spread, while others have shown the variant’s fitness is similar to that of viruses lacking the mutation.”People who become ill with the oseltamivir-resistant strain of A(H1N1) do not appear to become any more sick than people infected with ‘normal’ seasonal influenza,” the ECDC said in its press release.In addition, the ECDC report stated, “It also needs to be remembered that antiviral resistant is a relative not absolute term. Patients ill with viruses that are deemed resistant in the laboratory often still seem to benefit when they take antivirals.”See also:Jan 24 CIDRAP News story “Older flu drugs still used, against CDC advice”last_img read more

CRSG Honours Ekpo Duke with Tennis Tournament

first_imgIn his address, the State Director of Sports, Dr. Jude Amadi, who described tennis as one of the best sports in the world, said the tournament was mooted to discover young talents who would represent the state and the nation in future.Amadi charged the athletes to ensure they made the cut so as to be chosen to represent Team Cross River in upcoming sporting activities in the state.Earlier in a goodwill message Etubom Duke, said he appreciated the gesture done to him by the state sports commission and Calabar Sports Club by organising the tournament in his honour.He charged stakeholders and other well-meaning Nigerians to encourage kids to play tennis.The octogenarian who is a legend in the game in the country also promised to do his best to encourage tennis in the state.Former President, Calabar Sports Club, Eteidung Umo E.Umo-Otong, said he was pleased with the state government’s attitude of grooming primary and secondary schools students in order to nurture fresh tennis players from the grassroots level.Umo-Otong, said that the students should continually participate in sporting activities that would no doubt reduce redundancy and idleness.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Bassey Inyang in CalabarA four-day Tennis championship to honour a former Nigerian star player, 88 year-old Etubom Charles Ekpo Duke, has flagged off at the Calabar Sports Club. The tournament is sponsored by the state government and its Sports CommissionAddressing participants at the opening ceremony of the event, Chairman of the Sports Commission, Orok Duke, said the commission and Governor Ben Ayade’s administration would always remember the state’s legends in sports, especially when they are still alive.Duke said his commission was committed to support sport activities and appealed to individuals and organisations to sponsor sports for the development and employment of teeming youths.Duke said cash prizes would be awarded to those who excelled, and sundry prizes given to participants in the primary and secondary schools’ categories of the tournament.last_img read more

BRAZIL 2014:Keshi defends provisional list April 26

first_imgThe Nigeria Football Federation (NFF) technical committee will meet on April 26 in Abuja to deliberate on the country’s plans for the World Cup in Brazil.Committee chairman Chris Green told that the date has been set aside to  discuss the Super Eagles plans as regards Brazil 2014.This will include coach Stephen Keshi defending his provisional squad for the World Cup.“The committee will meet on April 26 to discuss the World Cup,” he said.“Expectations are very high and so we cannot afford to fail.”The original meeting on March 26 had to be called off after Keshi, citing flight difficulties from the USA could not make the meeting. The meeting was then rescheduled for April 8, but members were enraged to find that the coach was attending an event in Lagos instead and threatened to boycott the new date.NFF President Aminu Maigari and Technical Committee chairman Chris Green were forced to proceed on a fence-mending exercise after the meeting was rescheduled for a new date of April 22.The re-conciliatory moves appear to have yielded fruit, with majority of the aggrieved members confirming their attendance.But the trade-off is that Keshi is expected to face a tough and grueling time over his World Cup squad selection policy, with many member unconvinced about his reasons for excluding some players.last_img read more

Wellington, Conway Springs set to battle for Chaparral Tournament Championship tonight

first_img25 19 23 63 Wellington 76 Clearwater 64 13 Conway Springs 18 14 13 8 18 8 16 23 Conway Springs: Winter 5, Denney 8, Finstad 6, Hedrick 15, Schaffer 6, Murphy 6, Dugan 17. Total: 19 (5) 10-19 63. 64 76 10 Wellington Conway Springs 63 Belle Plaine 57 Wellington: Gilmore 9, Ca. Phelps 13, Co. Phelps 12, Frame 3, Snipes 27, King 13. Total: 14 (8) 25-33 57 Conway Springs 63 Belle Plaine 57The feisty Dragons met their cross-county rivals for the first time this season on the hardwood. They gave Conway Springs a battle to the end. But Josh Dugan and Christian Hedrick inside proved to be too much for the Dragons. Dugan scored 17 while Hedrick had 15. Belle Plaine was led by Brandon Happy with 21 points. The Dragons opened the game taking a quick 8-2 lead as Freshman Bo Gooch opened with two treys. The Dragons led 16-14 at the end of the first quarter. But Conway Springs zone pressure took its toll in the second quarter as the Cardinals would outscore the Dragons 19-10 and led 33-26 at the half. The Cardinals would up their lead to 45-34 at the end of three quarters. Belle Plaine would cut the margin to six in the final stanza thanks in part to Happy’s three 3-pointers. Belle Plaine will battle Clearwater for third place today. The game is scheduled for 4:30 p.m. Belle Plaine 26 14 Brandon Happy led Belle Plaine with Tracy McCue, Sumner Newscow — It will be an all Sumner County showdown for the Chaparral Roadrunner Classic Tournament Championship tonight. Both Wellington and Conway Springs took care of business Friday night and will play for the all the Chappy marbles tonight tentatively set for 6 p.m. We say tentatively because Wellington’s game Friday was an hour later than originally scheduled.Wellington defeated Clearwater 76-64. Earlier in the evening, Conway Springs would beat Belle Plaine 63-57. The Wellington-Conway Springs matchup will be a rematch of a hotly contested game at the the Kingman Tournament in December. Conway Springs won that one 52-51. This marks Wellington’s third consecutive year of qualifying for the Chaparral Tournament Championship game.Wellington 76 Clearwater 64Wellington’s A.J. Snipes scored 27 points his career high to help lead the Crusaders to its second consecutive victory over Clearwater. The Crusaders, who struggled against Chaparral 56-51 in the first round of this tournament Thursday, were hitting on all cylinders in the Friday night semifinal game that was never really in doubt. Snipes established the momentum early by hitting three 3-pointers in the first quarter as Wellington rolled to a 26-13 lead. From that point forward Clearwater could not establish any real momentum. It was able to cut the lead to 10 to open the second half, but Wellington would eventually return to form. Clearwater kept clawing late in the game but again Wellington was able to fight off the onslaught. Cade Phelps had 13 while Connor Phelps had 12. Clearwater Belle Plaine: Gooch 14, Osgood 7, Nolan 8, Stover 7, B. Happy 21. Total: 15 (8) 3-4 57. 12last_img read more