Bacteria as a Vast Unexplored Medicine Chest

first_img(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0 Most of our therapeutic agents have been derived from bacteria.  A new survey shows we have barely tapped the surface of potential medicines beneath our feet.Science Daily reported on a study of three desert soils from California, Arizona and Utah published in the May issue of Applied and Environmental Microbiology.  A team from Howard Hughes Medical Institute found “greater diversity of potentially useful products than was previously supposed” in the biosynthetic genes of soil bacteria, implying that “environmental bacteria have the potential to encode a large additional treasure trove of new medicines.”  The article explained where most of our medicines come from:Natural compounds have been the sources of the majority of new drugs approved by the US Food and Drug Administration, and bacteria have been the biggest single source of these therapeutically relevant compounds. Most bacterially-derived antibiotic and anticancer agents were discovered by culturing bacteria from environmental samples, and then examining the metabolites they produce in laboratory fermentation studies. But the vast majority of bacterial species cannot be cultured, which suggested that the world might be awash in potentially useful, but unknown bacterial metabolites.It seems that researchers will not soon run out of material to investigate: “the genomes of environmental bacteria could encode many additional drug-like molecules, including compounds that might serve, among other things, as new antibiotics and anticancer agents.”When you think of bacteria, do you think of health?  Maybe findings like this will help end a kind of microbial racism.  A few bad ones should not create bias against the majority that work hard to create a better world.This survey also suggests that bacteria originally had a useful function in the Creation paradigm.last_img read more

Feeding Farmers Week #4 – Suter Produce Farm

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Week #4 of Feeding Farmers was a unique one as the focus was on Agri-tourism at Suter Produce! They fed up too as we enjoyed kettle corn and warm donuts. The farm also features a cider press that dates back to the 1800’s, a corn maze and a school buses galore. The best part was shooting off their corn cannon! Dale visited with the Suter’s about the operation.last_img

6 Under-Appreciated Variables That Win Deals

first_img Essential Reading! Get my first book: The Only Sale Guide You’ll Ever Need “The USA Today bestseller by the star sales speaker and author of The Sales Blog that reveals how all salespeople can attain huge sales success through strategies backed by extensive research and experience.” Buy Now There are more variables to competing and winning in sales than your company, your products, or your pricing. Many of the variables are under-appreciated. They are also within your control. Here is a list of variables that may cause you to lose to your competition. Reversing them will move you towards greater success.Outworked: If there is a single variable to success that is within your control, it is your willingness to work. Really work, not just show up at work. There will always be people with more talent than you, as our gifts are not distributed equally. Some people have received gifts as the circumstances of their birth, gifts that you were not given. No one, however, can deprive you of your willingness to work harder. This is perhaps the easiest way to produce better results than your competitors, only requiring giving your work your full focus and attention. Only you can prevent yourself from being outworked.Out-studied: You have to improve your ability to improve. One of the very best ways you can boost your performance is by studying. You can read more than your competitor, and the statistics suggest that if you read one sales book, you will have done more than most in your field (and if you are going to read a sales book, let me recommend this one). You can read business books to improve your business acumen, and you can read a newspaper (I suggest the Wall St. Journal). You can listen to CNBC while you are on the treadmill. Not many of your competitors will read their prospective client’s financial reports. Nor will they go to the trouble to become an expert. If you want to be a trusted advisor, start by doing your homework.Outlasted: I called a prospective client for years without ever obtaining a meeting. My competitor had them locked down, or so I thought. I gave up and decided to seek an easier target. A year or so later, I called the prospective to schedule an appointment only to be told that they had just reviewed new companies and selected a new provider. I missed the window because I did not persist. Your willingness to persist over time is another variable within your control. It requires that you are disciplined about your approach and your pursuit plan. It also requires that you be resourceful enough to vary your strategy and stay top of mind. If someone is going to outlast another, be the one with greater determination and persistence.Out-communicated: Mistakenly, people believe that an email is an effective form of communication. As efficient as email is, it is inferior to other, more powerful mediums, like face-to-face meetings, video conferences, or the telephone. Every day, the poor hapless (and helpless, and hopeless) salespeople send emails to their dream client’s inboxes, only to have them deleted without so much as a glance. Sadly, they believe what they are doing is prospecting. You control the medium you use, the frequency, and the value of those communications. One of the first things I ever wrote on this blog was the need to have a presence, to show up. The more frequent and valuable the communication, the more you prevent yourself from being out-communicated.Out-flanked: In The New Rules for Building Consensus, there is an idea about there no longer being a decision-maker, even though someone is going to say yes. The main idea here is that many people cannot say yes by themselves, but can say no and stop a group of people from taking action on your initiative. The second section of Eat Their Lunch is titled: Wiring the Building. The idea is to locate the stakeholders who are going to influence a decision and make sure you gain their support. If you aren’t doing this work and your competitor is, you can be out-flanked, your competitor developing support deep and wide while you cling to your power sponsor. Get there first, establish the relationships throughout the organization and out-flank your competition.Out-skilled: A salesperson once told me that he had been in sales for thirty-four years. His manager added that the salesperson had the same year no less than thirty-four times. The gist was that he wasn’t getting any better. Are your skills improving? Are your results improving? One of the most detrimental beliefs to success is the idea that you know enough, you are good enough, and that no growth is available to you. You are better off believing the exact opposite, that you know too little, your results aren’t what they should be, and that you have much runway in front of you. It isn’t difficult to out-skill your competitors, most of whom aren’t proactive about their growth and development.With so much outside of your control, your best strategy is to work on what is within your control.last_img read more

Will contest 2020 election alone: Manjhi

first_imgHindustani Awam Morcha (Secular) president and former Bihar Chief Minister Jitan Ram Manjhi on Friday said his party would contest the 2020 Assembly election alone as allies RJD and Congress were taking decisions in mahagathbandhan (the grand alliance) on their own. Earlier, Mr. Manjhi had declared that his party would contest the Jharkhand Assembly election independently. “Both the Congress and the RJD do not pay heed to our demand and taking decisions unilaterally. During the Lok Sabha election, we told them to form a coordination committee so that decisions could be taken with the consent of all allies, but it was not done and they take decisions and impose them on us… So we have decided to leave the alliance,” he said. However, Congress State leader Akhilesh Prasad Singh and Rashtriya Lok Samata Party president Upendra Kushwaha said Mr. Manjhi was still in the mahagathbandhan.last_img read more

Florida Alum Tim Tebow Won A Celebrity Par-3 Contest

first_imgTim Tebow on the field before a game.GAINESVILLE, FL – OCTOBER 07: Tim Tebow watches the action during the game between the Florida Gators and the LSU Tigers at Ben Hill Griffin Stadium on October 7, 2017 in Gainesville, Florida. (Photo by Sam Greenwood/Getty Images)Former Florida quarterback Tim Tebow wasn’t able to make it as a professional signal-caller in the NFL, but perhaps he still has a chance to be a star athlete after all. Tebow, playing at TPC Scottsdale Wednesday, won the Phoenix Suns Charities Shot at Glory competition by putting his tee shot just 12 feet from the pin on the 16th hole. The shot won him $40,000 – which goes to his favorite charity.Okay, so maybe Tebow doesn’t really have a shot at being a professional golfer. But that’s definitely a shot that’s going to keep him coming back.last_img read more

Bloc Quebecois members reject Martine Ouellet in leadership confidence vote

first_imgMONTREAL – Bloc Quebecois members resoundingly rejected the leadership of Martine Ouellet in a confidence vote over the weekend, even as they chose to support her vision of a party that focuses on Quebec’s independence above all else.The party announced on Sunday that 32 per cent of members voted in favour of her leadership, whereas 67 per cent voted against.Ouellet has yet to publicly comment on the result, but has previously said she believed getting the support of 50 per cent plus one would give her the legitimacy to stay on as head of the party.She is expected to make an official statement on Monday.The Bloc has been in disarray since late February, when seven of its 10 members of Parliament quit over Ouellet’s leadership style.Of the three who remained, only two still backed her heading into the vote.Ouellet, 49, has been described by some as controlling and uncompromising, and many of her detractors accused her of focusing too sharply on Quebec independence instead of defending the province’s interests on the federal scene.In mid-May, the Bloc’s youth wing withdrew its support of Ouellet, who is also sitting as an Independent member in the Quebec legislature after stepping away from the Parti Quebecois caucus.The Bloc’s estimated 14,500 members were invited to vote by telephone or online in a two-day vote that ran Friday and Saturday.While members rejected Ouellet’s leadership, they appeared to support her vision of a party that is centred around independence above all else.Some 65 per cent of voters approved the idea that the Bloc should support Quebec independence in its daily actions and promote it at every opportunity.The voter participation rate was about 59 per cent, the party said.Ouellet is a former Quebec cabinet minister who previously ran twice, unsuccessfully, for the leadership of the Parti Quebecois.She has led the Bloc Quebecois since March 2017.One of her advisors, Gilbert Paquette, refused to say whether Ouellet is planning to resign, limiting himself to saying the party would “deprive itself of an extraordinary spokesperson.”But former Bloc leader Gilles Duceppe, who has been a vocal opponent of Ouellet, said he believes she will have no choice.“At 50 per cent plus one, it’s already ridiculous, at 32 (per cent), to me it seems clear,” he told The Canadian Press.Current party chairman Mario Beaulieu said it would be “difficult” for Ouellet to continue with only 32 per cent.“But we will let her make her statement,” he said at a news conference.The two MPs who supported Ouellet said they were disappointed with the lack of support for their leader, but pleased with the party’s support for a pro-sovereignty mandate.“It’s article one, it’s the fourth time we’ve spoken on it,” Marilene Gill said.“And it’s clear, what people want is an active and assumed promotion of independence.”Duceppe, for his part, said he was optimistic about the vote result, which he said could open the door for the party’s renewal.He compared the Bloc’s situation to that of the Progressive Conservatives following the 1993 federal election, when they were left with only two seats.He suggested the party organize a leadership convention to be held after the October provincial election.last_img read more

Brookfield buying Forest City Realty Trust for 114 billion including debt

first_imgTORONTO – Brookfield Asset Management Inc. says it will buy Forest City Realty Trust Inc. for $11.4 billion including debt.The asset manager says it has entered into a definitive agreement with the Cleveland-based property trust acquire its shares in an all-cash transaction.The acquisition will give Brookfield control of Forest City’s 6.3 million square feet of office space, 2.3 million square feet of life science assets mostly in the Cambridge, Mass. area, and 2.2 million square feet of retail space.Forest City also has five large-scale development projects in the New York area, San Francisco, and Washington, D.C. and 18,500 multi-family units for a total portfolio of more than 18 million square feet that will also be part of the deal.Brookfield is offering $25.35 per share for Forest City, which it says is a 26.6. per cent premium to the company’s closing price on June 15, a day before recent market speculation on a possible deal.The deal marks the second major U.S. property buy for Brookfield this year after it agreed to take over property trust GGP Inc.last_img read more

Woman gangraped on pretext of offering lift in Shamli village

first_imgMuzaffarnagar: A 22-year-old woman was allegedly abducted and raped by three youths on the pretext of giving her lift in neighbouring Shamli district, police said. The victim was given a lift by the accused who drove her on a bike to an isolated area in Khandarwali village under Kotwali police station area in the district on Thursday and took chances to rape her at pistol point, police said. According to a complaint lodged by the survivor’s mother, the woman has stepped out of her home to withdraw money from a bank for purchasing medicines when the accused offered her lift. A case has been registered and the hunt is on to nab the absconding accused, they added.last_img read more